Safety of pentavalent vaccines

Sustained Effectiveness of Monovalent and Pentavalent Rotavirus Vaccines in Children.

OBJECTIVE Using case-control methodology, we measured the vaccine effectiveness (VE) of the 2-dose monovalent rotavirus vaccine (RV1) and 3-dose pentavalent rotavirus vaccine (RV5) series given in infancy against rotavirus disease resulting in hospital emergency department or inpatient care. STUDY DESIGN Children were eligible for enrollment if they presented to any 1 of 3 hospitals in Atlant...

Pentavalent & other new combination vaccines: solutions in search of problems.

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Safety of poliomyelitis vaccines.

Ensuring safety of DNA vaccines

In 1990 a new approach for vaccination was invented involving injection of plasmid DNA in vivo, which elicits an immune response to the encoded protein. DNA vaccination can overcome most disadvantages of conventional vaccine strategies and has potential for vaccines of the future. However, today 15 years on, a commercial product still has not reached the market. One possible explanation could b...

Global Advisory Committee on Vaccine Safety review of pentavalent vaccine safety concerns in four Asian countries

Since 2008, Haemophilus influenza type b (Hib) vaccine has increasingly been introduced into Asian countries immunisation programmes. Hib vaccine has mainly been introduced as a combination pentavalent vaccine, which has replaced the traditional DTwP or DTPwP-HepB vaccines. As expected with the introduction of a new vaccine, there has been increased attention to serious adverse events following...